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Contemporary coronary artery bypass grafting
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《医学前沿(英文)》 2014年 第8卷 第4期 页码 395-398 doi: 10.1007/s11684-014-0374-7
Current evidence clearly demonstrates that coronary artery bypass grafting (CABG) remains the “gold standard” treatment for most patients with multivessel and left main stem disease. This article summarizes the relevant evidence basis demonstrating that CABG, in comparison to stenting, reduces mortality and subsequent myocardial infarction and the need for repeat revascularization. The article also describes the evidence basis to support the use of more arterial grafts during CABG and the current role of off-pump CABG.
关键词: coronary artery bypass grafting (CABG) coronary artery disease left main arterial grafts internal mammary artery off-pump CABG
《医学前沿(英文)》 2023年 第17卷 第1期 页码 75-84 doi: 10.1007/s11684-022-0950-1
关键词: drug-coated balloon left main high bleeding risk predilatation calcifield lesion percutaneous coronary intervention
Coronary leukocyte activation in relation to progression of coronary artery disease
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《医学前沿(英文)》 2016年 第10卷 第1期 页码 85-90 doi: 10.1007/s11684-016-0435-1
Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation markers in the coronary circulation. Monocyte and neutrophil CD11b, neutrophil CD66b expression and intracellular neutrophil myeloperoxidase (MPO) in the coronary arteries were determined by flow cytometry in patients undergoing coronary angiography. The primary outcome included fatal and nonfatal myocardial infarction or arterial vascular intervention due to unstable angina pectoris. In total 99 subjects who were included, 70 had CAD at inclusion (26 patients had single-vessel disease, 18 patients had two-vessel disease and 26 patients had three-vessel disease). The median follow-up duration was 2242 days (interquartile range: 2142–2358). During follow-up, 13 patients (13%) developed progression of CAD. Monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO measured in blood obtained from the coronary arteries were not associated with the progression of CAD. These data indicate that coronary monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO do not predict the risk of progression of CAD.
关键词: coronary artery disease inflammation integrin myeloperoxidase leukocyte activation
WANG Hong, HUANG Lan, JIN Jun, SONG Yaoming, GENG Zhaohua, YU Xuejun, QIN Jun, ZHAO Gang, GAO Yunhua, LIU Zheng
《医学前沿(英文)》 2007年 第1卷 第1期 页码 62-67 doi: 10.1007/s11684-007-0013-7
Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease
Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu
《医学前沿(英文)》 2020年 第14卷 第1期 页码 81-90 doi: 10.1007/s11684-019-0692-x
关键词: soluble C-type lectin-like receptor-2 coronary artery disease risk factor
SinoSCORE: a logistically derived additive prediction model for post-coronary artery bypass grafting
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《医学前沿(英文)》 2013年 第7卷 第4期 页码 477-485 doi: 10.1007/s11684-013-0284-0
This study aims to construct a logistically derived additive score for predicting in-hospital mortality risk in Chinese patients undergoing coronary artery bypass surgery (CABG). Data from 9839 consecutive CABG patients in 43 Chinese centers were collected between 2007 and 2008 from the Chinese Coronary Artery Bypass Grafting Registry. This database was randomly divided into developmental and validation subsets (9:1). The data in the developmental dataset were used to develop the model using logistic regression. Calibration and discrimination characteristics were assessed using the validation dataset. Thresholds were defined for each model to distinguish different risk groups. After excluding 275 patients with incomplete information, the overall mortality rate of the remaining 9564 patients was 2.5%. The SinoSCORE model was constructed based on 11 variables: age, preoperative NYHA stage III or IV, chronic renal failure, extracardiac arteriopathy, chronic obstructive pulmonary disease, preoperative atrial fibrillation or flutter (within 2βweeks), left ventricular ejection fraction, other elective surgery, combined valve procedures, preoperative critical state, and BMI. In the developmental dataset, calibration using a Hosmer-Lemeshow (HL) test was at =β0.44 and discrimination based on the area under the receiver operating characteristic curve (ROC) was 0.80. In the validation dataset, the HL test was at =β0.34 and the area under the ROC (AUC) was 0.78. A logistically derived additive model for predicting in-hospital mortality among Chinese patients undergoing CABG was developed based on the most up-to-date multi-center data from China.
关键词: coronary artery bypass grafting risk stratification in-hospital mortality
肠道菌群与冠状动脉疾病的发生风险 Article
胡嘉禄, 姚志峰, 唐敏娜, 唐春, 赵晓璠, 苏曦, 卢淡泊, 李秋荣, 王张生, 颜彦, 王则能
《工程(英文)》 2021年 第7卷 第12期 页码 1715-1724 doi: 10.1016/j.eng.2020.05.025
在过去的几年中,小规模队列研究发现肠道菌群随冠状动脉疾病出现而改变。既往研究中所发现的冠状动脉疾病患者肠道中富集或减少的微生物群,在其他冠状动脉疾病队列中是否具有可重复性,有待进一步研究和验证。本研究共纳入78 名受试者,其中19 例受试者无冠状动脉狭窄(Ctrl 组),14 例受试者冠状动脉狭窄程度小于50%(LT50 组),45 例受试者冠状动脉狭窄程度大于50%(GT50 组)。采集受试者粪便标本,并提取DNA 进行16S 核糖体RNA 基因测序。对可执行的分类操作单位(operational taxonomic units, OTU)进行分析以确定不同类群的分类单元,采用多变量logistic 回归分析检验所定义的分类单元是否能独立预测冠状动脉疾病风险。结果显示,δ-变形杆菌纲、梭杆菌属、嗜胆菌属、放线菌属和梭菌XIX属在Ctrl 组中富集;普雷沃氏菌科、副拟杆菌属和芽孢杆菌属在LT50 组中富集;罗氏菌属和丁酸单胞菌属在GT50 组中富集。δ-变形杆菌纲、梭杆菌属、嗜胆菌属和脱硫弧菌科种群的增加与冠状动脉疾病风险降低相关。在相对丰度高于中位数的个体中,冠状动脉疾病风险分别降低为相对丰度低于中位数的个体的0.26 倍、0.21 倍、0.18 倍和0.26 倍(p < 0.05),而普雷沃氏菌科种群的增加与冠状动脉疾病风险增加相关,冠状动脉疾病风险增加5.63 倍(p < 0.01)。使用20 种微生物群联合诊断LT50组与Ctrl组、GT50组与Ctrl组、LT50组+GT50组与Ctrl组、GT50组与Ctrl组+LT50组,受试者工作特征
(ROC)曲线下的面积均高于0.88。然而,除拟杆菌属外,既往研究所报道的在冠状动脉疾病或健康对照组受试者中富集的肠道菌群在本队列并未观察到。总之,冠状动脉疾病与健康对照组受试者具有不同的菌群特征。不同队列研究所发现的冠状动脉疾病富集的肠道菌群特征不具有重复性,提示肠道菌群较难应用于冠状动脉疾病的早期诊断和预防。综合本研究与既往研究结果,只有拟杆菌属丰度减少是冠状动脉疾病进展的可靠标志物。
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 437-442 doi: 10.1007/s11684-009-0074-x
关键词: natriuretic peptide precursor A coronary heart disease gene polymorphism allelic discrimination polymorphism single nucleotide
Cluster analysis for syndromes of real-world coronary heart disease with angina pectoris
Yufeng Zhao, Xueyun Yu, Xinyu Cao, Lin Luo, Liyun He, Shusong Mao, Li Ma, Peijing Rong, Yuxue Zhao, Guozheng Li, Baoyan Liu
《医学前沿(英文)》 2018年 第12卷 第5期 页码 566-571 doi: 10.1007/s11684-017-0556-1
Syndromes of coronary heart disease with angina pectoris were analyzed to provide guidance for clinical practice and to improve accuracy of traditional Chinese medicine (TCM) diagnoses and efficacy of TCM treatment. A total of 860 cases with coronary heart disease with angina pectoris were selected from TCM Clinical Research Information Sharing System for TCM clinics and research. Syndromes were automatically extracted with the cluster method and were analyzed to provide objective evidence for clinical studies. Final syndrome classifications were recognized and confirmed by clinical experts. Popular syndromes included Qi and blood deficiency, blood stasis and obstruction collaterals, liver depression and spleen deficiency, and Qi stagnation and blood stasis. Syndromes Qi and blood deficiency and blood stasis and obstruction collaterals accounted for 28.61% of total syndromes, whereas liver depression and spleen deficiency and Qi stagnation and blood stasis accounted for 26.44%. The main syndrome elements comprised Qi deficiency, blood deficiency, blood stasis, and Qi stagnation.
关键词: syndrome differentiation real-world study coronary heart disease with angina pectoris cluster analysis
Wei HAN MM, Ming-Xing XIE MD, Qing LV MD, Xin-Fang WANG MD, Li ZHANG MM,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 71-76 doi: 10.1007/s11684-010-0006-9
关键词: echocardiography twist two-dimensional strain imaging coronary artery disease
Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational
《医学前沿(英文)》 2022年 第16卷 第4期 页码 651-658 doi: 10.1007/s11684-021-0859-0
关键词: acute coronary syndrome (ACS) throat discomfort (TD) throat pain cardiology departments non-cardiologic physicians
The early percutaneous coronary intervention in elderly patients with acute coronary syndrome
HUANG Xiong, CAO Xuebin, ZHANG Gang
《医学前沿(英文)》 2008年 第2卷 第1期 页码 15-18 doi: 10.1007/s11684-008-0004-3
关键词: door-to-balloon percutaneous intervention coronary syndrome angioplasty successful
Translational research on novel drug-eluting stents in percutaneous coronary intervention
Yaling Han, Kai Xu, Chenghui Yan
《医学前沿(英文)》 2011年 第5卷 第4期 页码 395-400 doi: 10.1007/s11684-011-0167-1
关键词: translational research drug-eluting stents percutaneous coronary intervention
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《医学前沿(英文)》 2011年 第5卷 第1期 页码 86-93 doi: 10.1007/s11684-011-0118-x
Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development. Because of its structural homology to the endothelial mitogens, NT-1 may have similar effects on vascular network formation. NT-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothelial cells in vitro and also promote focal neovascularization in adult brain in vivo. In the present study, we reported the delivery of NT-1 using an adeno-associated virus (AAV) vector (AAV-NT-1) into mouse brain followed by transient middle cerebral artery occlusion (tMCAO). We found that AAV vectors did not elicit a detectable inflammatory response, cell loss or neuronal damage after brain transduction. The level of NT-1 was increased in the AAV-NT-1-transduced tMCAO mice compared with the control mice. Furthermore, the neurobehavioral outcomes were significantly improved in AAV-NT-1-transduced mice compared with the control animals (P<0.05) 7 days after tMCAO. Our data suggests that NT-1 plays a neuronal function recovery role in ischemic brain and that NT-1 gene transfer might present a valuable approach to treat brain ischemic disorders.
关键词: adeno-associated virus angiogenesis gene transfer ischemia middle cerebral artery occlusion netrin-1
Right coronary occlusion following transcatheter aortic valve implantation: two case reports
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《医学前沿(英文)》 2016年 第10卷 第3期 页码 351-355 doi: 10.1007/s11684-016-0465-8
This paper discusses two male patients with severe aortic stenosis, whose right coronary arteries (RCA) were completely occluded during transcatheter aortic valve implantation (TAVI), leading to fatal hemodynamic disorder. Occlusions of RCA complicated by TAVI are rare. In addition, emergency cardiopulmonary bypass (CPB) played a critical role in rescuing our second patient. Both patients were admitted for “severe aortic stenosis,” and TAVIs were performed. The first patient’s blood pressure immediately dropped to 70/40 mmHg after the balloon expansion and did not increase much after the administration of aramine or fluid therapy. He did not receive emergency surgery and died after 1.5 h of resuscitation. The second patient’s blood pressure fluctuated greatly for several minutes after the valve implantation, ranging from 170/100 mmHg to 60/40 mmHg. Angiography revealed a total occlusion of RCA. Thoracic surgery with CPB was performed, and the patient survived.
关键词: aortic stenosis transcatheter aortic valve implantation right coronary occlusion cardiac group
标题 作者 时间 类型 操作
Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary arterydisease: the importance of proper lesion preparation
期刊论文
Evaluation of the effect of myocardial perfusion after percutaneous coronary intervention in coronaryartery disease by using intracoronary myocardial contrast echocardiography and two other angiographic
WANG Hong, HUANG Lan, JIN Jun, SONG Yaoming, GENG Zhaohua, YU Xuejun, QIN Jun, ZHAO Gang, GAO Yunhua, LIU Zheng
期刊论文
Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease
Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu
期刊论文
SinoSCORE: a logistically derived additive prediction model for post-coronary artery bypass grafting
null
期刊论文
The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
期刊论文
Cluster analysis for syndromes of real-world coronary heart disease with angina pectoris
Yufeng Zhao, Xueyun Yu, Xinyu Cao, Lin Luo, Liyun He, Shusong Mao, Li Ma, Peijing Rong, Yuxue Zhao, Guozheng Li, Baoyan Liu
期刊论文
Assessment of global and regional left ventricular twist and displacement in anterior myocardial infarction using 2-dimensional strain imaging
Wei HAN MM, Ming-Xing XIE MD, Qing LV MD, Xin-Fang WANG MD, Li ZHANG MM,
期刊论文
Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational
期刊论文
The early percutaneous coronary intervention in elderly patients with acute coronary syndrome
HUANG Xiong, CAO Xuebin, ZHANG Gang
期刊论文
Translational research on novel drug-eluting stents in percutaneous coronary intervention
Yaling Han, Kai Xu, Chenghui Yan
期刊论文
Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery
null
期刊论文